ASSOCIATION BETWEEN HBA1C AND INFLAMMATORY MARKERS : HS-CRP AND HOMOCYSTEINE

Abstract

Introduction : Hyperglycemia is the condition that the body has high blood sugar levels results in the  insulin resistance and inflammation within the body. It can increase the level of inflammatory markers : hs-CRP and homocysteine in the blood. hs-CRP and homocysteine are  involved in inflammation within the body and also are associated with arteriosclerosis diseases such as coronary artery disease, stroke and peripheral vascular disease.

Objectives : Study the association between HbA1C and inflammatory markers levels: hs-CRP and homocysteine.

Methods : 90 cases, ages between 35 and 65 years were collected data from the Bangkok Anti-Aging Center’s medical records between July 2019 and March 2020.: Independent variable is HbA1c and dependent variables are hs-CRP and Homocysteine. Pearson’s Correlation Coefficient was used to detect the correlations between HbA1c and hs-CRP and Homocysteine.

Results : HbA1c was positively correlated with hs-CRP in the blood was statistically significant (r = 0.33, p = 0.001) and HbA1C also was positively correlated with Homocysteine was statistically significant (r = 0.53, p <0.001). In addition, BMI was positively correlated with hs-CRP, and Homocysteine with statistically significant r = 0.33 and 0.32 respectively and p = 0.002 and 0.002 respectively.

Conclusion : high levels of inflammatory markers were found not only in those diagnosed with diabetes, but in those with HbA1c diagnosed with Pre-diabetes were found to have high inflammatory markers as well. Therefore, if we can control HbA1c to normal level (HbA1c <5.7) without focusing only on people with diabetes but  in people who are Pre-diabetes. On adjusting diet and exercise to keep HbA1c and weight to normal level. It can help reduce inflammation within the body and blood vessels and help reduce arteriosclerosis in the future Which is an important and common complication in patients with hyperglycemia as well.